The Science

Cellular energy support, backed by the full stack.

NAD+ powers how every cell in your body produces energy. Rather than relying on NAD+ alone, we paired it with quercetin and resveratrol — two polyphenols studied specifically for potentiating the protective and metabolic effects of NAD+-supporting compounds. It's why we built Vault8 around this combination, not a single ingredient.

The problem.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme every cell needs to convert food into usable energy, repair DNA, and regulate metabolism. Research consistently shows NAD+ levels decline as we age, which has been linked to reduced cellular energy output and slower recovery.

Why NAD+ alone isn't the whole answer.

Oral NAD+ is a large, charged molecule, and how efficiently it survives digestion intact is still genuinely debated in the research. That's the honest caveat behind most NAD+ products on the market, including this one. It's also why we didn't stop at NAD+ — we paired it with quercetin and resveratrol, two compounds studied for supporting the same cellular pathways from a different angle.

Why quercetin and resveratrol.

Lab research has found that resveratrol and quercetin can potentiate the protective effects of NAD+-boosting compounds against cellular stress, and resveratrol has been reported to support NMNAT enzyme activity — a step involved in the body's own NAD+ production. Read the study

Quercetin and resveratrol also have a bioavailability problem on their own: taken separately, both are poorly absorbed. Research on combining the two has shown meaningfully enhanced absorption compared to either compound alone, which is part of the rationale for pairing them together rather than dosing a single polyphenol in isolation. Read the study

A 2023 review specifically examined combining micronutrients like quercetin and resveratrol with NAD+-promoting compounds as a strategy for supporting healthspan. Read the study

What is NAD+, exactly?

NAD+ is a coenzyme found in every cell in your body, required for converting food into usable energy and for repairing DNA. Your body produces it naturally, but that production slows with age — one of the most consistent findings in NAD+ research over the past two decades, including foundational work from Harvard Medical School's Sinclair Lab on NAD+'s role in aging and DNA repair, and on resveratrol's role activating the SIRT1 pathway connected to that same biology.

Ongoing research

NAD+ biology remains an active area of study. Multiple trials are currently underway examining long-term NAD+ precursor and cofactor supplementation in older adults, including the NADage Study (NCT06208527), a long-term randomized trial of NAD+ replenishment therapy against functional decline in aging.

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These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results from published research may not reflect outcomes for any specific product or individual, and are not a guarantee of results.